منابع مشابه
PTX3 acts as an extrinsic oncosuppressor.
Inflammation is an essential component of the tumor microenvironment that sustains tumor development and growth [1]. The role in cancer-related inflammation of innate immunity cells recruited in the tumor has been clarified in preclinical models. In contrast, the role of the humoral arm of the innate immune system, which includes biochemically heterogeneous molecules such as Complement componen...
متن کاملCD99 acts as an oncosuppressor in osteosarcoma.
CD99 was recently reported to be under control of the osteoblast-specific transcription factor Cbfa1 (RUNX2) in osteoblasts, suggesting a role in the phato-physiology of these cells. No extensive information is available on the role(s) of this molecule in malignant phenotype, and osteosarcoma, in particular, has never been studied. We report that in 11 different cell lines and 17 clinical sampl...
متن کاملPTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer
PTX3 is an essential component of the humoral arm of innate immunity, playing a nonredundant role in resistance against selected microbes and in the regulation of inflammation. PTX3 activates and regulates the Complement cascade by interacting with C1q and with Factor H. PTX3 deficiency was associated with increased susceptibility to mesenchymal and epithelial carcinogenesis. Increased suscepti...
متن کاملA Commentary on “PTX3 is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer”
Inflammation is a constant feature of tumors. The tumor microenvironment (TME) is rich in inflammatory cells and inflammatory mediators that strongly affect tumor growth and progression as well as metastatic spreading. It has been known for a while that tumor-infiltrating inflammatory cells such as myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAM) promote tumor gro...
متن کاملEpigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer
PTX3 is a component of the humoral arm of innate immunity and an extrinsic oncosuppressor gene taming tumor-promoting inflammation. Here, we show that two enhancers differently regulate PTX3 expression: enhancer 1, located 230 kb upstream of PTX3 promoter, mediated the action of inflammatory transcription factors; and enhancer 2, encompassing PTX3 second exon, was implicated in pre-initiation c...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.4845